| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
27pg/mL |
| Detection Limit: |
78.1-5000pg/mL |
| Short Description: |
This MIP3a Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Ccl20 |
| Gene ID: |
20297 |
| Uniprot ID: |
CCL20_MOUSE |
| Sample Type: |
serum, plasma or other biological fluids. |
| Tissue Specificity | Thymic medulla (at protein level). Prominently expressed in the small intestine, colon and appendix. Also found in thymus, spleen, lymph node and lung. The long form might be dominant in intestinal, and the short form in lymphoid tissues. Expressed by IL17 producing helper T-cells (Th17). |
| Post Translational Modifications | |
| Function | Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. |
| Protein Name | C-C Motif Chemokine 20Beta-Chemokine Exodus-1Cc Chemokine LarcCc Chemokine St38Liver And Activation-Regulated ChemokineMacrophage Inflammatory Protein 3 AlphaMip-3-AlphaSmall-Inducible Cytokine A20 |
| Database Links | Reactome: R-MMU-380108Reactome: -MMU-418594 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | C-C Motif Chemokine 20 ELISA kitBeta-Chemokine Exodus-1 ELISA kitCc Chemokine Larc ELISA kitCc Chemokine St38 ELISA kitLiver And Activation-Regulated Chemokine ELISA kitMacrophage Inflammatory Protein 3 Alpha ELISA kitMip-3-Alpha ELISA kitSmall-Inducible Cytokine A20 ELISA kitCcl20 ELISA kitLarc ELISA kitScya20 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
