Mouse MECOM protein (Recombinant) (N-His) (STJP011132)

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STJP011132
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse MECOM-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Mecom
Gene ID: 14013
Uniprot ID: MECOM_MOUSE
Immunogen Region: Asp74-Ser193
Immunogen: Mus musculus (Mouse)
Function Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Isoform 3: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.
Protein Name Histone-Lysine N-Methyltransferase Mecom
Ecotropic Virus Integration Site 1 Protein
Evi-1
Mds1 And Evi1 Complex Locus Protein
Myelodysplasia Syndrome 1 Protein Homolog
Cellular Localisation Nucleus
Nucleus Speckle
Cytoplasm
Alternative Protein Names Histone-Lysine N-Methyltransferase Mecom protein
Ecotropic Virus Integration Site 1 Protein protein
Evi-1 protein
Mds1 And Evi1 Complex Locus Protein protein
Myelodysplasia Syndrome 1 Protein Homolog protein
Mecom protein
Evi1 protein
Mds1 protein
Prdm3 protein

Information sourced from Uniprot.org

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