| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
5.1pg/mL |
| Detection Limit: |
12.5-800pg/mL |
| Short Description: |
This LOX1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Olr1 |
| Gene ID: |
108078 |
| Uniprot ID: |
OLR1_MOUSE |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | N-glycosylated. |
| Function | Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. |
| Protein Name | Oxidized Low-Density Lipoprotein Receptor 1Ox-Ldl Receptor 1Lectin-Like Oxidized Ldl Receptor 1Lox-1Lectin-Like Oxldl Receptor 1Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form |
| Database Links | Reactome: R-MMU-202733Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorSingle-Pass Type Ii Membrane ProteinMembrane RaftSecretedA Secreted Form Also ExistsLocalization To Membrane Rafts Requires Palmitoylation |
| Alternative ELISA Names | Oxidized Low-Density Lipoprotein Receptor 1 ELISA kitOx-Ldl Receptor 1 ELISA kitLectin-Like Oxidized Ldl Receptor 1 ELISA kitLox-1 ELISA kitLectin-Like Oxldl Receptor 1 ELISA kitLectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form ELISA kitOlr1 ELISA kitLox1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
