• Mouse LOX1 (Lectin Like Oxidized Low Density Lipoprotein Receptor 1) Sandwich ELISA Kit (STJE0010380)

Mouse LOX1 (Lectin Like Oxidized Low Density Lipoprotein Receptor 1) Sandwich ELISA Kit (STJE0010380)

SKU:
STJE0010380

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 5.1pg/mL
Detection Limit: 12.5-800pg/mL
Short Description: This LOX1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Olr1
Gene ID: 108078
Uniprot ID: OLR1_MOUSE
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications N-glycosylated.
Function Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Protein Name Oxidized Low-Density Lipoprotein Receptor 1
Ox-Ldl Receptor 1
Lectin-Like Oxidized Ldl Receptor 1
Lox-1
Lectin-Like Oxldl Receptor 1
Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form
Database Links Reactome: R-MMU-202733
Reactome: -MMU-6798695
Cellular Localisation Cell Membrane
Lipid-Anchor
Single-Pass Type Ii Membrane Protein
Membrane Raft
Secreted
A Secreted Form Also Exists
Localization To Membrane Rafts Requires Palmitoylation
Alternative ELISA Names Oxidized Low-Density Lipoprotein Receptor 1 ELISA kit
Ox-Ldl Receptor 1 ELISA kit
Lectin-Like Oxidized Ldl Receptor 1 ELISA kit
Lox-1 ELISA kit
Lectin-Like Oxldl Receptor 1 ELISA kit
Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form ELISA kit
Olr1 ELISA kit
Lox1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance