| Function | Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. When secreted, interacts with NK cell-activating receptor NCR3/NKp30 acting as an inhibitory ligand which antagonizes NK cell attack. |
| Protein Name | Galectin-3Gal-335 Kda LectinCarbohydrate-Binding Protein 35Cbp 35Galactose-Specific Lectin 3Ige-Binding ProteinL-34 Galactoside-Binding LectinLaminin-Binding ProteinLectin L-29Mac-2 Antigen |
| Cellular Localisation | CytoplasmNucleusSecretedSecreted By A Non-Classical Secretory Pathway And Associates With The Cell SurfaceCan Be SecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Protein Names | Galectin-3 proteinGal-3 protein35 Kda Lectin proteinCarbohydrate-Binding Protein 35 proteinCbp 35 proteinGalactose-Specific Lectin 3 proteinIge-Binding Protein proteinL-34 Galactoside-Binding Lectin proteinLaminin-Binding Protein proteinLectin L-29 proteinMac-2 Antigen proteinLgals3 protein |
Information sourced from Uniprot.org
