| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 7.2pg/mL |
| Detection Limit: | 15.6-1000pg/mL |
| Short Description: | This KLb Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | Klb |
| Gene ID: | 83379 |
| Uniprot ID: | KLOTB_MOUSE |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Present in liver, muscle and white adipose tissue, but not in kidney (at protein level). Expressed in liver and pancreas, and at lower levels in skin, stomach, skeletal muscle, small intestine and lung. |
| Post Translational Modifications | |
| Function | Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. |
| Protein Name | Beta-KlothoBklBetaklothoKlotho Beta-Like Protein |
| Database Links | Reactome: R-MMU-109704Reactome: -MMU-1257604Reactome: -MMU-1307965Reactome: -MMU-5654228Reactome: -MMU-5654712Reactome: -MMU-5654719Reactome: -MMU-5654720Reactome: -MMU-5654733Reactome: -MMU-5673001Reactome: -MMU-6811558 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane Protein |
| Alternative ELISA Names | Beta-Klotho ELISA kitBkl ELISA kitBetaklotho ELISA kitKlotho Beta-Like Protein ELISA kitKlb ELISA kitBetakl ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
