| Tissue Specificity | |
| Post Translational Modifications | Phosphorylated on a serine residue after mast cell stimulation with immunoglobulin E (IgE). |
| Function | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. |
| Protein Name | Lysine--Trna LigaseLysyl-Trna SynthetaseLysrs |
| Database Links | Reactome: R-MMU-9856649 |
| Cellular Localisation | CytoplasmCytosolNucleusCell MembranePeripheral Membrane ProteinSecretedSecretion Is Induced By Tnf-AlphaCytosolic In Quiescent Mast CellsTranslocates Into The Nucleus In Response To Mast Cell Activation By Immunoglobulin E |
| Alternative ELISA Names | Lysine--Trna Ligase ELISA kitLysyl-Trna Synthetase ELISA kitLysrs ELISA kitKars1 ELISA kitKars ELISA kit |
| output | |
Information sourced from Uniprot.org
