| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.053ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This IPF Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Pdx1 |
| Gene ID: |
18609 |
| Uniprot ID: |
PDX1_MOUSE |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). |
| Post Translational Modifications | Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-269 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol. |
| Function | Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer.the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CCCTTAATGGG-3'. |
| Protein Name | Pancreas/Duodenum Homeobox Protein 1Insulin Promoter Factor 1Ipf-1Islet/Duodenum Homeobox 1Idx-1Somatostatin-Transactivating Factor 1Stf-1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative ELISA Names | Pancreas/Duodenum Homeobox Protein 1 ELISA kitInsulin Promoter Factor 1 ELISA kitIpf-1 ELISA kitIslet/Duodenum Homeobox 1 ELISA kitIdx-1 ELISA kitSomatostatin-Transactivating Factor 1 ELISA kitStf-1 ELISA kitPdx1 ELISA kitIpf1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
