Mouse IL3 protein (Recombinant-Active) (C-His) (STJP011778)

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STJP011778-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Mouse IL3-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: Il3
Gene ID: 16187
Uniprot ID: IL3_MOUSE
Immunogen Region: Met1-Cys166
Immunogen: Mus musculus (Mouse)
Function Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
Protein Name Interleukin-3
Il-3
Hematopoietic Growth Factor
Mast Cell Growth Factor
Mcgf
Multipotential Colony-Stimulating Factor
P-Cell-Stimulating Factor
Database Links Reactome: R-MMU-512988
Reactome: -MMU-5673001
Reactome: -MMU-912526
Cellular Localisation Secreted
Alternative Protein Names Interleukin-3 protein
Il-3 protein
Hematopoietic Growth Factor protein
Mast Cell Growth Factor protein
Mcgf protein
Multipotential Colony-Stimulating Factor protein
P-Cell-Stimulating Factor protein
Il3 protein
Csfmu protein
Il-3 protein

Information sourced from Uniprot.org

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