| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse IL-1 R1/IL-1 RI-C-Fc protein was developed from hek293 cells and has a target region of C-Fc. For use in research applications. |
| Formulation: |
Lyophilized from a 0.2 Mu m filtered solution of PBS, pH7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Il1r1 |
| Gene ID: |
16177 |
| Uniprot ID: |
IL1R1_MOUSE |
| Immunogen Region: |
Leu20-Lys338 |
| Immunogen: |
Recombinant Mouse IL-1 R1/IL-1 RI Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Leu20-Lys338) of mouse IL-1 R1/IL-1 RI (Accession #P13504) fused with an Fc tag at the C-terminus. |
| Post Translational Modifications | A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). Rapidly phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1. |
| Function | Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. Isoform 2: Unable to mediate canonical IL-1 signaling. Cooperates with IL1RAP isoform 3 to mediate IL1B-induced neuronal activity including IL1B-potentiated NMDA-induced calcium influx mediated by Akt kinase activation. |
| Protein Name | Interleukin-1 Receptor Type 1Il-1r-1Il-1rt-1Il-1rt1Cd121 Antigen-Like Family Member AInterleukin-1 Receptor AlphaIl-1r-AlphaInterleukin-1 Receptor Type IP80Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane FormMil-1r1Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble FormSil-1r1Sil-1ri |
| Database Links | Reactome: R-MMU-9020702 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell MembraneSecreted |
| Alternative Protein Names | Interleukin-1 Receptor Type 1 proteinIl-1r-1 proteinIl-1rt-1 proteinIl-1rt1 proteinCd121 Antigen-Like Family Member A proteinInterleukin-1 Receptor Alpha proteinIl-1r-Alpha proteinInterleukin-1 Receptor Type I proteinP80 proteinCd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form proteinMil-1r1 proteinMil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form proteinSil-1r1 proteinSil-1ri proteinIl1r1 proteinIl-1r1 proteinIl1ra protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
