| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.055ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This HTT Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
HttUniprot ID=HD_MOUSE" |
| Sample Type: |
serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | The highest level is seen throughout the brain, but it is also found in the stomach, heart, testis, adipose tissue, muscle, spleen, liver, and kidney. |
| Post Translational Modifications | Phosphorylation at Ser-1159 and Ser-1179 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Huntingtin: Cleaved by caspases downstream of the polyglutamine stretch. Huntingtin, myristoylated N-terminal fragment: Myristoylated at Gly-530, following proteolytic cleavage at Asp-529. |
| Function | Huntingtin: May play a role in microtubule-mediated transport or vesicle function. Huntingtin, myristoylated N-terminal fragment: Promotes the formation of autophagic vesicles. |
| Protein Name | HuntingtinHuntington Disease Protein HomologHd Protein Homolog Cleaved Into - Huntingtin - Myristoylated N-Terminal Fragment |
| Database Links | |
| Cellular Localisation | Huntingtin: CytoplasmNucleusShuttles Between Cytoplasm And Nucleus In A Ran Gtpase-Independent MannerHuntingtinMyristoylated N-Terminal Fragment: Cytoplasmic VesicleAutophagosome |
| Alternative ELISA Names | Huntingtin ELISA kitHuntington Disease Protein Homolog ELISA kitHd Protein Homolog Cleaved Into - Huntingtin - Myristoylated N-Terminal Fragment ELISA kitHtt ELISA kitHd ELISA kitHdh ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
