| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.045ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This GRIN2A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Grin2a |
| Gene ID: |
14811 |
| Uniprot ID: |
NMDE1_MOUSE |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Detected in striatum. Detected in forbrain. Detected in cerebellum (at protein level). Detected in brain cortex, piriform cortex, hippocampus, caudate-putamen, dentate gyrus and granule cell layer. |
| Post Translational Modifications | |
| Function | Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 2aGlun2aGlutamate Nmda Receptor Subunit Epsilon-1N-Methyl D-Aspartate Receptor Subtype 2aNmdar2aNr2a |
| Database Links | Reactome: R-MMU-438066Reactome: -MMU-8849932Reactome: -MMU-9609736 |
| Cellular Localisation | Cell ProjectionDendritic SpineCell MembraneMulti-Pass Membrane ProteinSynapsePostsynaptic Cell MembraneCytoplasmic Vesicle MembraneExpression At The Dendrite Cell Membrane And At Synapses Is Regulated By Sorcs2 And The Retromer Complex |
| Alternative ELISA Names | Glutamate Receptor Ionotropic - Nmda 2a ELISA kitGlun2a ELISA kitGlutamate Nmda Receptor Subunit Epsilon-1 ELISA kitN-Methyl D-Aspartate Receptor Subtype 2a ELISA kitNmdar2a ELISA kitNr2a ELISA kitGrin2a ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
