Applications: | ELISA |
Reactivity: | Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 0.073ng/mL |
Detection Limit: | 0.156-10ng/mL |
Short Description: | This GRIA4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
Assay Time: | 3 hrs |
Gene Symbol: | Gria4 |
Gene ID: | 14802 |
Uniprot ID: | GRIA4_MOUSE |
Immunogen Region: | Ready-To-Use |
Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
Tissue Specificity | |
Post Translational Modifications | Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylated at Ser-862 by PRKCG.phosphorylation increases plasma membrane-associated GRI4 expression. |
Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
Protein Name | Glutamate Receptor 4 Glur-4 Glur4 Ampa-Selective Glutamate Receptor 4 Glur-D Glutamate Receptor Ionotropic - Ampa 4 Glua4 |
Database Links | Reactome: R-MMU-399710 Reactome: -MMU-399719 Reactome: -MMU-416993 Reactome: -MMU-438066 Reactome: -MMU-8849932 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Postsynaptic Cell Membrane Cell Projection Dendrite Interaction With Cnih2 Cnih3 And Prkcg Promotes Cell Surface Expression |
Alternative ELISA Names | Glutamate Receptor 4 ELISA kit Glur-4 ELISA kit Glur4 ELISA kit Ampa-Selective Glutamate Receptor 4 ELISA kit Glur-D ELISA kit Glutamate Receptor Ionotropic - Ampa 4 ELISA kit Glua4 ELISA kit Gria4 ELISA kit Glur4 ELISA kit |
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Information sourced from Uniprot.org