• Mouse GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4) Sandwich ELISA Kit (STJE0009298)

Mouse GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4) Sandwich ELISA Kit (STJE0009298)

SKU:
STJE0009298

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.073ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This GRIA4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Gria4
Gene ID: 14802
Uniprot ID: GRIA4_MOUSE
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylated at Ser-862 by PRKCG.phosphorylation increases plasma membrane-associated GRI4 expression.
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Protein Name Glutamate Receptor 4
Glur-4
Glur4
Ampa-Selective Glutamate Receptor 4
Glur-D
Glutamate Receptor Ionotropic - Ampa 4
Glua4
Database Links Reactome: R-MMU-399710
Reactome: -MMU-399719
Reactome: -MMU-416993
Reactome: -MMU-438066
Reactome: -MMU-8849932
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Cell Projection
Dendrite
Interaction With Cnih2
Cnih3 And Prkcg Promotes Cell Surface Expression
Alternative ELISA Names Glutamate Receptor 4 ELISA kit
Glur-4 ELISA kit
Glur4 ELISA kit
Ampa-Selective Glutamate Receptor 4 ELISA kit
Glur-D ELISA kit
Glutamate Receptor Ionotropic - Ampa 4 ELISA kit
Glua4 ELISA kit
Gria4 ELISA kit
Glur4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance