| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse GPVI-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Supplied as a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Gp6 |
| Gene ID: |
243816 |
| Uniprot ID: |
GPVI_MOUSE |
| Immunogen Region: |
Gln22-Lys265 |
| Immunogen: |
Recombinant Mouse GPVI Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln22-Lys265) of mouse GPVI (Accession #NP_001156486.1) fused with a 6×His tag at the C-terminus. |
| Function | Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. |
| Protein Name | Platelet Glycoprotein ViGpviGlycoprotein 5 |
| Database Links | Reactome: R-MMU-114604Reactome: -MMU-202733Reactome: -MMU-75892 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane Protein |
| Alternative Protein Names | Platelet Glycoprotein Vi proteinGpvi proteinGlycoprotein 5 proteinGp6 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
