| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse GAS-6-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
1.Immobilized Mouse GAS6, His Tag at 5 Mu g/m l (100 Mu l/well) on the plate. Dose response curve for Human AXL, hFc Tag with the EC50 of 3.1ng/ml determined by ELISA (QC Test).2.Mouse AXL, His Tag immobilized on CM5 Chip can bind Mouse GAS6, His Tag |
| Gene Symbol: |
Gas6 |
| Gene ID: |
14456 |
| Uniprot ID: |
GAS6_MOUSE |
| Immunogen Region: |
Val28-Pro674 |
| Immunogen: |
Recombinant Mouse GAS-6 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val28-Pro674) of mouse GAS-6 (Accession #NP_062394.2) fused with a 6×His tag at the C-terminus. |
| Function | Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. |
| Protein Name | Growth Arrest-Specific Protein 6Gas-6Axl Receptor Tyrosine Kinase Ligand |
| Database Links | Reactome: R-MMU-114608Reactome: -MMU-159763Reactome: -MMU-159782Reactome: -MMU-202733Reactome: -MMU-381426Reactome: -MMU-8957275 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Growth Arrest-Specific Protein 6 proteinGas-6 proteinAxl Receptor Tyrosine Kinase Ligand proteinGas6 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
