• Mouse ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Sandwich ELISA Kit Ready-To-Use (STJE0015030)

Mouse ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Sandwich ELISA Kit Ready-To-Use (STJE0015030)

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STJE0015030

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.065ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ENPP2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Enpp2
Gene ID: 18606
Uniprot ID: ENPP2_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Expressed in brain and adipose tissue.
Post Translational Modifications N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity. Secretion requires simultaneous glycosylation on Asn-53 and Asn-410, while probable glycosylation of Asn-410 has a preferential role on lysoPLD activity. Not O-glycosylated. The interdomain disulfide bond between Cys-413 and Cys-805 is essential for catalytic activity.
Function Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor. Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids. Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF).
Protein Name Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2
E-Npp 2
Autotaxin
Extracellular Lysophospholipase D
Lysopld
Database Links
Cellular Localisation Secreted
Alternative ELISA Names Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2 ELISA kit
E-Npp 2 ELISA kit
Autotaxin ELISA kit
Extracellular Lysophospholipase D ELISA kit
Lysopld ELISA kit
Enpp2 ELISA kit
Npps2 ELISA kit
Pdnp2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance