| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse ENPP-2/Autotaxin-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Endotoxin: |
Less than 1EU per Mu g by the LAL method. |
| Gene Symbol: |
Enpp2 |
| Gene ID: |
18606 |
| Uniprot ID: |
ENPP2_MOUSE |
| Immunogen Region: |
Ser49-Ile862 |
| Immunogen: |
Recombinant Mouse ENPP-2/Autotaxin Protein is expressed from Expi293 with His tag at the C-terminal.；It contains Ser49-Ile862. |
| Post Translational Modifications | N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity. Secretion requires simultaneous glycosylation on Asn-53 and Asn-410, while probable glycosylation of Asn-410 has a preferential role on lysoPLD activity. Not O-glycosylated. The interdomain disulfide bond between Cys-413 and Cys-805 is essential for catalytic activity. |
| Function | Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor. Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids. Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF). |
| Protein Name | Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2E-Npp 2AutotaxinExtracellular Lysophospholipase DLysopld |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2 proteinE-Npp 2 proteinAutotaxin proteinExtracellular Lysophospholipase D proteinLysopld proteinEnpp2 proteinNpps2 proteinPdnp2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
