• Mouse CDH2 (Cadherin, Neuronal) Sandwich ELISA Kit Ready-To-Use (STJE0014210)

Mouse CDH2 (Cadherin, Neuronal) Sandwich ELISA Kit Ready-To-Use (STJE0014210)

SKU:
STJE0014210

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.065ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This CDH2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Cdh2
Gene ID: 12558
Uniprot ID: CADH2_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in cardiac muscle (at protein level).
Post Translational Modifications Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa N-terminal soluble fragment and a 45 kDa membrane-bound C-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence. May be phosphorylated by OBSCN. O-glycosylated on Ser and Thr residues.
Function Calcium-dependent cell adhesion protein.preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells. Required for proper neurite branching. Required for pre- and postsynaptic organization. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Protein Name Cadherin-2
Neural Cadherin
N-Cadherin
Cd Antigen Cd325
Database Links Reactome: R-MMU-381426
Reactome: -MMU-418990
Reactome: -MMU-525793
Reactome: -MMU-8957275
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Sarcolemma
Cell Junction
Adherens Junction
Desmosome
Cell Surface
Colocalizes With Tmem65 At The Intercalated Disk In Cardiomyocytes
Colocalizes With Obscn At The Intercalated Disk And Sarcolemma In Cardiomyocytes
Alternative ELISA Names Cadherin-2 ELISA kit
Neural Cadherin ELISA kit
N-Cadherin ELISA kit
Cd Antigen Cd325 ELISA kit
Cdh2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance