| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | Cd70 |
| Gene ID: | 21948 |
| Uniprot ID: | CD70_MOUSE |
| Immunogen Region: | Glu53-Arg195 |
| Immunogen: | Recombinant Mouse CD70/TNFSF7/CD27 Ligand Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu53-Arg195) of Mouse CD70/TNFSF7/CD27 Ligand (Accession #NP_035747.1) fused with a His tag at the N-term |
| Immunogen Sequence: | EHPEPHTAELQLNLTVPRKD PTLRWGAGPALGRSFTHGPE LEEGHLRIHQDGLYRLHIQV TLANCSSPGSTLQHRATLAV GICSPAAHGISLLRGRFGQD CTVALQR |
| Post Translational Modifications | N-glycosylated. |
| Function | Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells. |
| Protein Name | Cd70 AntigenCd27 LigandCd27-LTumor Necrosis Factor Ligand Superfamily Member 7Cd Antigen Cd70 |
| Database Links | Reactome: R-MMU-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Cd70 Antigen proteinCd27 Ligand proteinCd27-L proteinTumor Necrosis Factor Ligand Superfamily Member 7 proteinCd Antigen Cd70 proteinCd70 proteinCd27l proteinCd27lg proteinTnfsf7 protein |
Information sourced from Uniprot.org
