Mouse B7-H4 protein (Recombinant) (STJP000645)

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STJP000645
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse B7-H4-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Gene Symbol: Vtcn1
Gene ID: 242122
Uniprot ID: VTCN1_MOUSE
Immunogen Region: PHE29-SER256
Immunogen: Optimized DNA sequence encoding mature chain of mouse B7-H4 (PHE29-SER256) including a C-terminal His tag was expressed in HEK293 cells. NA
Tissue Specificity Expressed on the surface of professional antigen-presenting cells (at protein level). Widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus.
Post Translational Modifications N-glycosylated.
Function Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Protein Name V-Set Domain Containing T-Cell Activation Inhibitor 1
B7 Homolog 4
B7-H4
Immune Costimulatory Protein B7-H4
Protein B7s1
T Cell Costimulatory Molecule B7x
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Expressed At The Cell Surface
A Soluble Form Has Also Been Detected
Alternative Protein Names V-Set Domain Containing T-Cell Activation Inhibitor 1 protein
B7 Homolog 4 protein
B7-H4 protein
Immune Costimulatory Protein B7-H4 protein
Protein B7s1 protein
T Cell Costimulatory Molecule B7x protein
Vtcn1 protein
B7h4 protein

Information sourced from Uniprot.org

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