| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
5.9pg/mL |
| Detection Limit: |
15.6-1000pg/mL |
| Short Description: |
This APLNR Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Aplnr |
| Gene ID: |
23796 |
| Uniprot ID: |
APJ_MOUSE |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in coronary endothelial cells (at protein level). Expressed in the embryo, allantoic and endothelial precursor cells of the yolk sac at 8 days post-coitum (dpc). Expressed in the secondary heart field and somite at 8.25 dpc. Expressed in fetal allantoic endothelial cells at 9 dpc. Expressed in the allantoid and the invading fetal vasculature of the placenta at 9.5 dpc. Expressed in endothelial cells adjacent to syncytiotrophoblast cells at 10.5 dpc. Expressed weakly in the embryonic heart at 11.5 dpc. Expressed in the adult heart. Expressed in endothelial cells and cardiomyocytes and weakly expressed in fibroblasts. |
| Post Translational Modifications | |
| Function | Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure. |
| Protein Name | Apelin ReceptorAngiotensin Receptor-Like 1G-Protein Coupled Receptor ApjMsr |
| Database Links | Reactome: R-MMU-375276Reactome: -MMU-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinAfter Exposure To Apelin (Apln) Or Apelin Receptor Early Endogenous Ligand (Apela)Internalized From The Cell Surface Into An Endosomal Recycling CompartmentFrom Where It Is Recycled To The Cell Membrane |
| Alternative ELISA Names | Apelin Receptor ELISA kitAngiotensin Receptor-Like 1 ELISA kitG-Protein Coupled Receptor Apj ELISA kitMsr ELISA kitAplnr ELISA kitAgtrl1 ELISA kitApj ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
