| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
IRAKM Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:2, 500-1:5, 000 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
IRAK3 |
| Gene ID: |
11213 |
| Uniprot ID: |
IRAK3_HUMAN |
| Immunogen: |
Purified Interleukin-1 receptor-associated kinase 3 protein. |
| Tissue Specificity | Expressed in eosinophils, dendritic cells and/or monocytes (at protein level). Expressed predominantly in peripheral blood lymphocytes. |
| Function | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells. |
| Peptide Name | Interleukin-1 Receptor-Associated Kinase 3Irak-3Il-1 Receptor-Associated Kinase MIrak-MInactive Il-1 Receptor-Associated Kinase 3 |
| Database Links | Reactome: R-HSA-166058Reactome: R-HSA-9020702 |
| Cellular Localisation | CytoplasmNucleusIn Dendritic CellsTranslocates Into The Nucleus Upon Il33 Stimulation |
| Alternative Peptide Names | Interleukin-1 Receptor-Associated Kinase 3 proteinIrak-3 proteinIl-1 Receptor-Associated Kinase M proteinIrak-M proteinInactive Il-1 Receptor-Associated Kinase 3 proteinIRAK3 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
