IP3 receptor Positive Control peptide (STJ504328)

SKU:
STJ504328-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: IP3 receptor Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ITPR1
Gene ID: 3708
Uniprot ID: ITPR1_HUMAN
Tissue Specificity Widely expressed.
Post Translational Modifications Phosphorylated on tyrosine residues. Ubiquitination at multiple lysines targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'-linked. Phosphorylated by cAMP kinase (PKA). Phosphorylation prevents the ligand-induced opening of the calcium channels. Phosphorylation by PKA increases the interaction with inositol 1,4,5-trisphosphate and decreases the interaction with AHCYL1. Palmitoylated by ZDHHC6 in immune cells, leading to regulation of ITPR1 stability and function.
Function Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
Peptide Name Inositol 1 -4 -5-Trisphosphate Receptor Type 1
Ip3 Receptor Isoform 1
Ip3r 1
Insp3r1
Type 1 Inositol 1 -4 -5-Trisphosphate Receptor
Type 1 Insp3 Receptor
Database Links Reactome: R-HSA-112043
Reactome: R-HSA-114508
Reactome: R-HSA-139853
Reactome: R-HSA-1489509
Reactome: R-HSA-2029485
Reactome: R-HSA-2871809
Reactome: R-HSA-381676
Reactome: R-HSA-4086398
Reactome: R-HSA-418457
Reactome: R-HSA-422356
Reactome: R-HSA-5218921
Reactome: R-HSA-5578775
Reactome: R-HSA-5607763
Reactome: R-HSA-9664323
Reactome: R-HSA-983695
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Cytoplasmic Vesicle
Secretory Vesicle Membrane
Cytoplasm
Perinuclear Region
Endoplasmic Reticulum And Secretory Granules
Alternative Peptide Names Inositol 1 -4 -5-Trisphosphate Receptor Type 1 protein
Ip3 Receptor Isoform 1 protein
Ip3r 1 protein
Insp3r1 protein
Type 1 Inositol 1 -4 -5-Trisphosphate Receptor protein
Type 1 Insp3 Receptor protein
ITPR1 protein
INSP3R1 protein

Information sourced from Uniprot.org

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