HYPE Blocking Peptide for STJ506116 peptide (STJ505840)

SKU:
STJ505840-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: HYPE Blocking Peptide for STJ506116 is synthetically produced from the 400-450 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: FICD
Gene ID: 11153
Uniprot ID: FICD_HUMAN
Immunogen Region: 400-450
Specificity: This blocking peptide is recommended for use in combination with HYPE antibody, STJ506116
Immunogen: Synthetic peptide corresponding to amino acids within region 400-450 on mouse Protein adenylyltransferase FICD.
Tissue Specificity Ubiquitous.
Post Translational Modifications Auto-AMPylated in vitro.it is unclear whether auto-AMPylation is relevant in vivo. N-glycosylated.predominantly glycosylated at Asn-275.
Function Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context. The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP. In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it. In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity. Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates.
Peptide Name Protein Adenylyltransferase Ficd
Ampylator Ficd
De-Ampylase Ficd
Fic Domain-Containing Protein
Huntingtin Yeast Partner E
Huntingtin-Interacting Protein 13
Hip-13
Huntingtin-Interacting Protein E
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Alternative Peptide Names Protein Adenylyltransferase Ficd protein
Ampylator Ficd protein
De-Ampylase Ficd protein
Fic Domain-Containing Protein protein
Huntingtin Yeast Partner E protein
Huntingtin-Interacting Protein 13 protein
Hip-13 protein
Huntingtin-Interacting Protein E protein
FICD protein
HIP13 protein
HYPE protein
UNQ3041 protein
PRO9857 protein

Information sourced from Uniprot.org

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