• Human VEGFC (Vascular Endothelial Growth Factor C) Sandwich ELISA Kit (STJE0007144)

Human VEGFC (Vascular Endothelial Growth Factor C) Sandwich ELISA Kit (STJE0007144)

SKU:
STJE0007144

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 23.7pg/mL
Detection Limit: 62.5-4000pg/mL
Short Description: This VEGFC Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: VEGFC
Gene ID: 7424
Uniprot ID: VEGFC_HUMAN
Sample Type: serum, platelet-poor plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte.
Post Translational Modifications Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
Function Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.
Protein Name Vascular Endothelial Growth Factor C
Vegf-C
Flt4 Ligand
Flt4-L
Vascular Endothelial Growth Factor-Related Protein
Vrp
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-194313
Reactome: R-HSA-195399
Cellular Localisation Secreted
Alternative ELISA Names Vascular Endothelial Growth Factor C ELISA kit
Vegf-C ELISA kit
Flt4 Ligand ELISA kit
Flt4-L ELISA kit
Vascular Endothelial Growth Factor-Related Protein ELISA kit
Vrp ELISA kit
VEGFC ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance