| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.053ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This UBR4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
UBR4 |
| Gene ID: |
23352 |
| Uniprot ID: |
UBR4_HUMAN |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ubr4600 Kda Retinoblastoma Protein-Associated FactorN-Recognin-4Ring-Type E3 Ubiquitin Transferase Ubr4Retinoblastoma-Associated Factor Of 600 KdaRbaf600P600Zinc Finger Ubr1-Type Protein 1 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-983168 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmCytoskeletonNucleusConcentrates At The Leading Edge Of Membrane Structures Involved In Actin Motility |
| Alternative ELISA Names | E3 Ubiquitin-Protein Ligase Ubr4 ELISA kit600 Kda Retinoblastoma Protein-Associated Factor ELISA kitN-Recognin-4 ELISA kitRing-Type E3 Ubiquitin Transferase Ubr4 ELISA kitRetinoblastoma-Associated Factor Of 600 Kda ELISA kitRbaf600 ELISA kitP600 ELISA kitZinc Finger Ubr1-Type Protein 1 ELISA kitUBR4 ELISA kitKIAA0462 ELISA kitKIAA1307 ELISA kitRBAF600 ELISA kitZUBR1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
