• Human SMURF1 (Human E3 Ubiquitin-Protein Ligase SMURF1) Sandwich ELISA Kit (STJE0012243)

Human SMURF1 (Human E3 Ubiquitin-Protein Ligase SMURF1) Sandwich ELISA Kit (STJE0012243)

SKU:
STJE0012243

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 31.3pg/mL
Detection Limit: 78-5000pg/mL
Short Description: This SMURF1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SMURF1
Gene ID: 57154
Uniprot ID: SMUF1_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Expressed in melanocytes.
Post Translational Modifications Auto-ubiquitinated in presence of NDFIP1. Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site.
Function E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS. Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation. Plays a role in dendrite formation by melanocytes.
Protein Name E3 Ubiquitin-Protein Ligase Smurf1
Hsmurf1
Hect-Type E3 Ubiquitin Transferase Smurf1
Smad Ubiquitination Regulatory Factor 1
Smad-Specific E3 Ubiquitin-Protein Ligase 1
Database Links Reactome: R-HSA-201451
Reactome: R-HSA-2173788
Reactome: R-HSA-2173791
Reactome: R-HSA-4608870
Reactome: R-HSA-5632684
Reactome: R-HSA-8939902
Reactome: R-HSA-8941858
Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Alternative ELISA Names E3 Ubiquitin-Protein Ligase Smurf1 ELISA kit
Hsmurf1 ELISA kit
Hect-Type E3 Ubiquitin Transferase Smurf1 ELISA kit
Smad Ubiquitination Regulatory Factor 1 ELISA kit
Smad-Specific E3 Ubiquitin-Protein Ligase 1 ELISA kit
SMURF1 ELISA kit
KIAA1625 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance