| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.64ng/mL |
| Detection Limit: |
1.56-100ng/mL |
| Short Description: |
This UBQLN2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
UBQLN2 |
| Gene ID: |
29978 |
| Uniprot ID: |
UBQL2_HUMAN |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Degraded during macroautophagy. |
| Function | Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation.required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs). |
| Protein Name | Ubiquilin-2Chap1Dsk2 HomologProtein Linking Iap With Cytoskeleton 2Plic-2Hplic-2Ubiquitin-Like Product Chap1/Dsk2 |
| Database Links | Reactome: R-HSA-8856825 |
| Cellular Localisation | CytoplasmNucleusMembraneCytoplasmic VesicleAutophagosomeColocalizes With A Subset Of ProteasomesNamely Those That Are Cytoskeleton Associated Or Free In The CytosolAssociated With Fibers In Mitotic Cells |
| Alternative ELISA Names | Ubiquilin-2 ELISA kitChap1 ELISA kitDsk2 Homolog ELISA kitProtein Linking Iap With Cytoskeleton 2 ELISA kitPlic-2 ELISA kitHplic-2 ELISA kitUbiquitin-Like Product Chap1/Dsk2 ELISA kitUBQLN2 ELISA kitN4BP4 ELISA kitPLIC2 ELISA kitHRIHFB2157 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
