Human TTK protein (Recombinant) (N-His) (STJP004581)

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STJP004581
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TTK-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TTK
Gene ID: 7272
Uniprot ID: TTK_HUMAN
Immunogen Region: Gly532-Ala787
Immunogen: Homo sapiens (Human)
Function Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates.
Protein Name Dual Specificity Protein Kinase Ttk
Phosphotyrosine Picked Threonine-Protein Kinase
Pyt
Alternative Protein Names Dual Specificity Protein Kinase Ttk protein
Phosphotyrosine Picked Threonine-Protein Kinase protein
Pyt protein
TTK protein
MPS1 protein
MPS1L1 protein

Information sourced from Uniprot.org

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