| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Active Recombinant-Human TSLP (R127A, R130A)-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human TSLP at 2 Mu g/mL (100 Mu L/well) can bind Recombinant Human TSLPR with a linear range of 20-90 ng/mL. |
| Gene Symbol: |
TSLP |
| Gene ID: |
85480 |
| Uniprot ID: |
TSLP_HUMAN |
| Immunogen Region: |
Tyr29-Gln159Arg127Ala, Arg130Ala |
| Immunogen: |
Recombinant Human TSLP (R127A, R130A) Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Tyr29-Gln159 (Arg127Ala, Arg130Ala) ) of human TSLP (Accession #NP_149024.1) fused with a 6×His tag at the C-t |
| Tissue Specificity | Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva. |
| Function | Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin. |
| Protein Name | Thymic Stromal Lymphopoietin |
| Database Links | Reactome: R-HSA-1266695 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Thymic Stromal Lymphopoietin proteinTSLP protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
