| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.040ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This TNKS2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
TNKS2 |
| Gene ID: |
80351 |
| Uniprot ID: |
TNKS2_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain. |
| Post Translational Modifications | Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated.this leads to degradation. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer. |
| Function | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity. |
| Protein Name | Poly Adp-Ribose Polymerase Tankyrase-2Adp-Ribosyltransferase Diphtheria Toxin-Like 6Artd6Poly Adp-Ribose Polymerase 5bProtein Poly-Adp-Ribosyltransferase Tankyrase-2Tnks-2Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2Tankyrase IiTankyrase-2Tank2Tankyrase-Like ProteinTankyrase-Related Protein |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-4641257Reactome: R-HSA-5545619Reactome: R-HSA-5689880Reactome: R-HSA-8948751 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinNucleusChromosomeTelomereAssociated With The Golgi And With Juxtanuclear Slc2a4/Glut4-VesiclesAlso Found Around The Pericentriolar Matrix Of Mitotic CentromeresDuring InterphaseA Small Fraction Of Tnks2 Is Found In The NucleusAssociated With Trf1 |
| Alternative ELISA Names | Poly Adp-Ribose Polymerase Tankyrase-2 ELISA kitAdp-Ribosyltransferase Diphtheria Toxin-Like 6 ELISA kitArtd6 ELISA kitPoly Adp-Ribose Polymerase 5b ELISA kitProtein Poly-Adp-Ribosyltransferase Tankyrase-2 ELISA kitTnks-2 ELISA kitTrf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2 ELISA kitTankyrase Ii ELISA kitTankyrase-2 ELISA kitTank2 ELISA kitTankyrase-Like Protein ELISA kitTankyrase-Related Protein ELISA kitTNKS2 ELISA kitPARP5B ELISA kitTANK2 ELISA kitTNKL ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
