• Human TLR3 (Toll Like Receptor 3) Sandwich ELISA Kit Ready-To-Use (STJE0019020)

Human TLR3 (Toll Like Receptor 3) Sandwich ELISA Kit Ready-To-Use (STJE0019020)

SKU:
STJE0019020

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 28pg/mL
Detection Limit: 78.1-5000pg/mL
Short Description: This TLR3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: TLR3
Gene ID: 7098
Uniprot ID: TLR3_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.
Post Translational Modifications Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding. TLR3 signaling requires a proteolytic cleavage mediated by cathepsins CTSB and CTSH, the cleavage occurs between amino acids 252 and 346. The cleaved form of TLR3 is the predominant form found in endosomes. Ubiquitinated by TRIM3.leading to recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes. Ubiquitinated by ZNRF1 via 'Lys-63'-linked ubiquitin chains.leading to TLR3 lysosomal trafficking and degradation.
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
Protein Name Toll-Like Receptor 3
Cd Antigen Cd283
Database Links Reactome: R-HSA-1679131
Reactome: R-HSA-168164
Reactome: R-HSA-168927
Reactome: R-HSA-1810476
Reactome: R-HSA-5602410
Reactome: R-HSA-5602415
Reactome: R-HSA-5602566
Reactome: R-HSA-5602571
Reactome: R-HSA-9013957
Reactome: R-HSA-9013973
Reactome: R-HSA-9014325
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Endosome Membrane
Early Endosome
Alternative ELISA Names Toll-Like Receptor 3 ELISA kit
Cd Antigen Cd283 ELISA kit
TLR3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance