| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.148ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This SYN1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
SYN1 |
| Gene ID: |
6853 |
| Uniprot ID: |
SYN1_HUMAN |
| Sample Type: |
tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Substrate of different protein kinases. Phosphorylated by CaMK2 and MAPK1. Phosphorylation, including phosphorylation at Ser-9, promotes synapsin-1 dissociation from synaptic vesicles, regulates its rate of dispersion, and controls the kinetics of vesicle pool turnover and neurotransmitter release . |
| Function | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal. Also involved in the regulation of axon outgrowth and synaptogenesis. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. |
| Protein Name | Synapsin-1Brain Protein 4.1Synapsin I |
| Database Links | Reactome: R-HSA-181429Reactome: R-HSA-212676Reactome: R-HSA-9662360 |
| Cellular Localisation | SynapseGolgi ApparatusPresynapseCytoplasmic VesicleSecretory VesicleSynaptic VesicleDissociates From Synaptic Vesicles And Redistributes Into The Axon During Action Potential FiringIn A Step That Precedes Fusion Of Vesicles With The Plasma MembraneReclusters To Presynapses After The Cessation Of Synaptic Activity |
| Alternative ELISA Names | Synapsin-1 ELISA kitBrain Protein 4.1 ELISA kitSynapsin I ELISA kitSYN1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
