| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.62ng/mL |
| Detection Limit: |
1.56-100ng/mL |
| Short Description: |
This SULF1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
SULF1 |
| Gene ID: |
23213 |
| Uniprot ID: |
SULF1_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines. |
| Post Translational Modifications | Processing by furin produces a secreted form. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. |
| Function | Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. |
| Protein Name | Extracellular Sulfatase Sulf-1Hsulf-1ArylsulfataseN-Acetylglucosamine-6-Sulfatase Cleaved Into - Extracellular Sulfatase Sulf-2 Secreted Form |
| Database Links | |
| Cellular Localisation | Endoplasmic ReticulumGolgi ApparatusGolgi StackCell SurfaceExtracellular Sulfatase Sulf-2 Secreted Form: Secreted |
| Alternative ELISA Names | Extracellular Sulfatase Sulf-1 ELISA kitHsulf-1 ELISA kitArylsulfatase ELISA kitN-Acetylglucosamine-6-Sulfatase Cleaved Into - Extracellular Sulfatase Sulf-2 Secreted Form ELISA kitSULF1 ELISA kitKIAA1077 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
