| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.105ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This SSH1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
SSH1 |
| Gene ID: |
54434 |
| Uniprot ID: |
SSH1_HUMAN |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase. |
| Function | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. |
| Protein Name | Protein Phosphatase Slingshot Homolog 1Ssh-Like Protein 1Ssh-1lHssh-1l |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionLamellipodiumCleavage FurrowMidbodyAlso Recruited To Actin Rich Membrane Protrusions Such As LamellipodiaWhich May Allow Local Control Of Actin Dynamics At Sites Of Cell LocomotionAlso Localized To The Cleavage Furrow And The Midbody During Cytokinesis |
| Alternative ELISA Names | Protein Phosphatase Slingshot Homolog 1 ELISA kitSsh-Like Protein 1 ELISA kitSsh-1l ELISA kitHssh-1l ELISA kitSSH1 ELISA kitKIAA1298 ELISA kitSSH1L ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
