Human SMARCA2 protein (Recombinant) (N-His) (STJP010113)

SKU:
STJP010113
£427.50 - £2,311.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Insect Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SMARCA2-N-His protein was developed from insect cells and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SMARCA2
Gene ID: 6595
Uniprot ID: SMCA2_HUMAN
Immunogen Region: Glu636-Asp1331
Immunogen: Homo sapiens (Human)
Function Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Protein Name Probable Global Transcription Activator Snf2l2
Atp-Dependent Helicase Smarca2
Brg1-Associated Factor 190b
Baf190b
Protein Brahma Homolog
Hbrm
Snf2-Alpha
Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 2
Database Links Reactome: R-HSA-3214858
Reactome: R-HSA-8939243
Reactome: R-HSA-9824585
Reactome: R-HSA-9845323
Cellular Localisation Nucleus
Localizes To Sites Of Dna Damage
Alternative Protein Names Probable Global Transcription Activator Snf2l2 protein
Atp-Dependent Helicase Smarca2 protein
Brg1-Associated Factor 190b protein
Baf190b protein
Protein Brahma Homolog protein
Hbrm protein
Snf2-Alpha protein
Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 2 protein
SMARCA2 protein
BAF190B protein
BRM protein
SNF2A protein
SNF2L2 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP005172 Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172) E. coli
STJP004723 Human WAS protein (Recombinant) (N-His) (STJP004723) E. coli
STJP011678 Human FSTL1 protein (Recombinant) (N-His) (STJP011678) E. coli
STJP003644 Human ALDOA protein (Recombinant) (N-His) (STJP003644) E. coli
STJP003667 Human KRT1 protein (Recombinant) (N-His) (STJP003667) E. coli

Related Products

!