| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.107ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This SLC30A5 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
SLC30A5 |
| Gene ID: |
64924 |
| Uniprot ID: |
ZNT5_HUMAN |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells (at protein level). |
| Post Translational Modifications | Could homodimerize through the formation of dityrosine bonds upon oxidative stress. |
| Function | Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis. Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin. Isoform 2: Zinc ion:proton antiporter mediating influx and efflux of zinc at the plasma membrane. |
| Protein Name | Proton-Coupled Zinc Antiporter Slc30a5Solute Carrier Family 30 Member 5Zinc Transporter 5Znt-5Znt-Like Transporter 1Hztl1 |
| Database Links | Reactome: R-HSA-264876Reactome: R-HSA-435368 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleCopii-Coated Vesicle MembraneSecretory Vesicle MembraneTrans-Golgi Network MembraneEnriched In Early Compartments Of The Secretory Pathway Including Copii-Coated Vesicles And The Golgi Cis CisternaIsoform 2: Endoplasmic Reticulum MembraneCell MembraneApical Cell Membrane |
| Alternative ELISA Names | Proton-Coupled Zinc Antiporter Slc30a5 ELISA kitSolute Carrier Family 30 Member 5 ELISA kitZinc Transporter 5 ELISA kitZnt-5 ELISA kitZnt-Like Transporter 1 ELISA kitHztl1 ELISA kitSLC30A5 ELISA kitZNT5 ELISA kitZNTL1 ELISA kitZTL1 ELISA kitUNQ863 ELISA kitPRO1879 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
