| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.054ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This SLC30A10 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
SLC30A10 |
| Gene ID: |
55532 |
| Uniprot ID: |
ZNT10_HUMAN |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Specifically expressed in fetal liver and fetal brain. Expressed in adult tissues with relative levels small intestine > liver > testes > brain > ovary > colon > cervix > prostate > placenta. Expressed in liver and neurons of the nervous system (at protein level). |
| Post Translational Modifications | |
| Function | Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange. Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes. |
| Protein Name | Calcium/Manganese Antiporter Slc30a10Solute Carrier Family 30 Member 10Zinc Transporter 10Znt-10 |
| Database Links | Reactome: R-HSA-425410 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneRecycling Endosome MembraneEarly Endosome MembraneLocalization To The Golgi And Plasma Membrane Is Regulated By Zinc |
| Alternative ELISA Names | Calcium/Manganese Antiporter Slc30a10 ELISA kitSolute Carrier Family 30 Member 10 ELISA kitZinc Transporter 10 ELISA kitZnt-10 ELISA kitSLC30A10 ELISA kitZNT10 ELISA kitZNT8 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
