• Human SFRP1 (Secreted Frizzled Related Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0018507)

Human SFRP1 (Secreted Frizzled Related Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0018507)

SKU:
STJE0018507

Shipping:
Free Shipping
Current Stock:
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.055ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This SFRP1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: SFRP1
Gene ID: 6422
Uniprot ID: SFRP1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes.
Post Translational Modifications
Function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
Protein Name Secreted Frizzled-Related Protein 1
Frp-1
Sfrp-1
Secreted Apoptosis-Related Protein 2
Sarp-2
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-3772470
Cellular Localisation Secreted
Cell Membrane Or Extracellular Matrix-Associated
Released By Heparin-Binding
Alternative ELISA Names Secreted Frizzled-Related Protein 1 ELISA kit
Frp-1 ELISA kit
Sfrp-1 ELISA kit
Secreted Apoptosis-Related Protein 2 ELISA kit
Sarp-2 ELISA kit
SFRP1 ELISA kit
FRP ELISA kit
FRP1 ELISA kit
SARP2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance