Human sCD163 (Scavenger Receptor Cysteine-Rich Type 1 Protein M130) Antibody Pair (STJAP00192)

SKU:
STJAP00192-50
£499.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Mouse/Mouse
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This sCD163 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Monoclonal/Monoclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Protein A or G.
Detection Purification: Protein A or G.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: CD163
Gene ID: 9332
Uniprot ID: C163A_HUMAN
Immunogen: Capture immunogen: Recombinant Human sCD163 protein.
Detection Immunogen: Recombinant Human sCD163 protein.
Post Translational Modifications A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. Phosphorylated.
Function Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Protein Name Scavenger Receptor Cysteine-Rich Type 1 Protein M130
Hemoglobin Scavenger Receptor
Cd Antigen Cd163 Cleaved Into - Soluble Cd163
Scd163
Database Links Reactome: R-HSA-2168880
Reactome: R-HSA-9662834
Cellular Localisation Soluble Cd163: Secreted
Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 1 And Isoform 2 Show A Lower Surface Expression When Expressed In Cells
Alternative Antibody Pair Names Scavenger Receptor Cysteine-Rich Type 1 Protein M130 antibody pair
Hemoglobin Scavenger Receptor antibody pair
Cd Antigen Cd163 Cleaved Into - Soluble Cd163 antibody pair
Scd163 antibody pair
CD163 antibody pair
M130 antibody pair

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP000663 Human Scavenger Receptor Class B Type I protein (Recombinant) (STJP000663) HEK293
STJAP00182 Human BMPR2 (Bone Morphogenetic Protein Receptor Type-2) Antibody Pair (STJAP00182) Mouse/Rabbit Monoclonal/Polyclonal Human ELISA
STJAP00252 Human TFR1 (Transferrin Receptor Protein 1) Antibody Pair (STJAP00252) Mouse/Mouse Monoclonal/Monoclonal Human ELISA
STJAP00402 Human IL-1R1 (Interleukin-1 Receptor Type 1) Antibody Pair (STJAP00402) Goat/Goat Human ELISA
STJE0008147 Human CRIP1 (Cysteine Rich Protein 1, Intestinal) Sandwich ELISA Kit Kit (STJE0008147) Human ELISA
!