• Human RYR1 (Ryanodine Receptor 1, Skeletal) Sandwich ELISA Kit Ready-To-Use (STJE0018347)

Human RYR1 (Ryanodine Receptor 1, Skeletal) Sandwich ELISA Kit Ready-To-Use (STJE0018347)

SKU:
STJE0018347

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.27ng/mL
Detection Limit: 0.781-50ng/mL
Short Description: This RYR1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: RYR1
Gene ID: 6261
Uniprot ID: RYR1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Skeletal muscle and brain (cerebellum and hippocampus).
Post Translational Modifications Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2843 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2843. Activated by reversible S-nitrosylation. Repeated very high-level exercise increases S-nitrosylation.
Function Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis.
Protein Name Ryanodine Receptor 1
Ryr-1
Ryr1
Skeletal Muscle Calcium Release Channel
Skeletal Muscle Ryanodine Receptor
Skeletal Muscle-Type Ryanodine Receptor
Type 1 Ryanodine Receptor
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-5578775
Cellular Localisation Sarcoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
The Number Of Predicted Transmembrane Domains Varies Between Orthologs
Both N-Terminus And C-Terminus Are Cytoplasmic
Alternative ELISA Names Ryanodine Receptor 1 ELISA kit
Ryr-1 ELISA kit
Ryr1 ELISA kit
Skeletal Muscle Calcium Release Channel ELISA kit
Skeletal Muscle Ryanodine Receptor ELISA kit
Skeletal Muscle-Type Ryanodine Receptor ELISA kit
Type 1 Ryanodine Receptor ELISA kit
RYR1 ELISA kit
RYDR ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance