| Host: |
HEK293 Cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human REG3A-C-6His protein was developed from hek293 cells and has a target region of C-6His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
REG3A |
| Gene ID: |
5068 |
| Uniprot ID: |
REG3A_HUMAN |
| Immunogen Region: |
Glu27-Asp175 |
| Immunogen: |
Recombinant Human REG3A Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Glu27-Asp175) of human REG3A (Accession #NP_002571.1) fused with a 6×His tag at the C-terminus. |
| Post Translational Modifications | Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. |
| Function | Regenerating islet-derived protein 3-alpha 15 kDa form: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore. Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation. Regenerating islet-derived protein 3-alpha 16.5 kDa form: Has bacteriostatic activity. |
| Protein Name | Regenerating Islet-Derived Protein 3-AlphaReg-3-AlphaHepatointestinal Pancreatic ProteinHip/PapHuman Proislet PeptideHipPancreatitis-Associated Protein 1Regenerating Islet-Derived Protein Iii-AlphaReg Iii-Alpha Cleaved Into - Regenerating Islet-Derived Protein 3-Alpha 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Alpha 15 Kda Form |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedFound In The Apical Region Of Pancreatic Acinar Cells |
| Alternative Protein Names | Regenerating Islet-Derived Protein 3-Alpha proteinReg-3-Alpha proteinHepatointestinal Pancreatic Protein proteinHip/Pap proteinHuman Proislet Peptide proteinHip proteinPancreatitis-Associated Protein 1 proteinRegenerating Islet-Derived Protein Iii-Alpha proteinReg Iii-Alpha Cleaved Into - Regenerating Islet-Derived Protein 3-Alpha 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Alpha 15 Kda Form proteinREG3A proteinHIP proteinPAP proteinPAP1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
