• Human RALBP1 (RalA Binding Protein 1) Sandwich ELISA Kit (STJE0011816)

Human RALBP1 (RalA Binding Protein 1) Sandwich ELISA Kit (STJE0011816)

SKU:
STJE0011816

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.058ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This RALBP1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: RALBP1
Gene ID: 10928
Uniprot ID: RBP1_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.
Post Translational Modifications Tyrosine-phosphorylated upon stimulation of cells with EGF. May undergo proteolytic cleavage to give peptides which reassemble to form a transporter complex.
Function Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity. As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L. Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance.
Protein Name Rala-Binding Protein 1
Ralbp1
76 Kda Ral-Interacting Protein
Dinitrophenyl S-Glutathione Atpase
Dnp-Sg Atpase
Ral-Interacting Protein 1
Database Links Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Cytoplasm
Cytosol
Cytoskeleton
Spindle Pole
Nucleus
Mitochondrion
Cytosolic Protein That Transiently Associates With The Mitotic Spindle Poles In Early Prophase
And Dissociates From Them After Completion Of Mitosis
Targeted To The Plasma Membrane Through Its Interaction With Ralb
Directed By Fgf Signaling
Docking On The Membrane Is Required To Transduce The Ral Signal
Recruited By Rala To The Mitochondrion During Mitosis Where It Regulates Mitochondrial Fission
Nuclear Localization Is Cell Cycle Dependent While Membrane Localization Is Seen In Adherent Cells
The Region Involved In Membrane Association Could Form Transmembrane Domains And Expose A Part Of The Protein Extracellularly (Probable)
Alternative ELISA Names Rala-Binding Protein 1 ELISA kit
Ralbp1 ELISA kit
76 Kda Ral-Interacting Protein ELISA kit
Dinitrophenyl S-Glutathione Atpase ELISA kit
Dnp-Sg Atpase ELISA kit
Ral-Interacting Protein 1 ELISA kit
RALBP1 ELISA kit
RLIP ELISA kit
RLIP1 ELISA kit
RLIP76 ELISA kit
output

Information sourced from Uniprot.org

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