| Function | Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by beta-galactosidase and globotriaosylceramide by alpha-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator. Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. |
| Protein Name | ProsaposinProactivator Polypeptide Cleaved Into - Saposin-AProtein A - Saposin-B-Val - Saposin-BCerebroside Sulfate ActivatorCsactDispersinSphingolipid Activator Protein 1Sap-1Sulfatide/Gm1 Activator - Saposin-CA1 ActivatorCo-Beta-GlucosidaseGlucosylceramidase ActivatorSphingolipid Activator Protein 2Sap-2 - Saposin-DComponent CProtein C |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-375276Reactome: R-HSA-418594Reactome: R-HSA-6798695Reactome: R-HSA-9840310 |
| Cellular Localisation | LysosomeProsaposin: SecretedSecreted As A Fully Glycosylated 70 Kda Protein Composed Of Complex Glycans |
| Alternative Protein Names | Prosaposin proteinProactivator Polypeptide Cleaved Into - Saposin-A proteinProtein A - Saposin-B-Val - Saposin-B proteinCerebroside Sulfate Activator proteinCsact proteinDispersin proteinSphingolipid Activator Protein 1 proteinSap-1 proteinSulfatide/Gm1 Activator - Saposin-C proteinA1 Activator proteinCo-Beta-Glucosidase proteinGlucosylceramidase Activator proteinSphingolipid Activator Protein 2 proteinSap-2 - Saposin-D proteinComponent C proteinProtein C proteinPSAP proteinGLBA proteinSAP1 protein |
Information sourced from Uniprot.org
