Applications: | ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 12.3pg/mL |
Detection Limit: | 31.2-2000pg/mL |
Short Description: | This PRDX4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
Assay Time: | 4.5 hrs |
Gene Symbol: | PRDX4 |
Gene ID: | 10549 |
Uniprot ID: | PRDX4_HUMAN |
Sample Type: | serum, plasma or other biological fluids. |
Tissue Specificity | |
Post Translational Modifications | The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. |
Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. |
Protein Name | Peroxiredoxin-4 Antioxidant Enzyme Aoe372 Aoe37-2 Peroxiredoxin Iv Prx-Iv Thioredoxin Peroxidase Ao372 Thioredoxin-Dependent Peroxide Reductase A0372 Thioredoxin-Dependent Peroxiredoxin 4 |
Database Links | Reactome: R-HSA-6798695 |
Cellular Localisation | Cytoplasm Endoplasmic Reticulum Cotranslationally Translocated To And Retained Within The Endoplasmic Reticulum A Small Fraction Of The Protein Is Cytoplasmic |
Alternative ELISA Names | Peroxiredoxin-4 ELISA kit Antioxidant Enzyme Aoe372 ELISA kit Aoe37-2 ELISA kit Peroxiredoxin Iv ELISA kit Prx-Iv ELISA kit Thioredoxin Peroxidase Ao372 ELISA kit Thioredoxin-Dependent Peroxide Reductase A0372 ELISA kit Thioredoxin-Dependent Peroxiredoxin 4 ELISA kit PRDX4 ELISA kit |
output |
Information sourced from Uniprot.org