• Human PLCz1 (Phospholipase C Zeta 1) Sandwich ELISA Kit (STJE0011541)

Human PLCz1 (Phospholipase C Zeta 1) Sandwich ELISA Kit (STJE0011541)

SKU:
STJE0011541

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.117ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This PLCz1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: PLCZ1
Gene ID: 89869
Uniprot ID: PLCZ1_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed specifically in testis and sperm. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic-duct cells from patients with cystic fibrosis.
Post Translational Modifications
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Protein Name 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Zeta-1
Phosphoinositide Phospholipase C-Zeta-1
Phospholipase C-Zeta-1
Plc-Zeta-1
Testis-Development Protein Nyd-Sp27
Database Links Reactome: R-HSA-1855204
Cellular Localisation Nucleus
Cytoplasm
Perinuclear Region
Exhibits Alternative Cytoplasmic/Nuclear Localization During Development
Translocates From The Pronucleus Into Cytoplasm Upon Nuclear Envelope Breakdown For Mitosis And Localizes Again To The Pronucleus At Interphase Following Meiosis And Mitosis
Alternative ELISA Names 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Zeta-1 ELISA kit
Phosphoinositide Phospholipase C-Zeta-1 ELISA kit
Phospholipase C-Zeta-1 ELISA kit
Plc-Zeta-1 ELISA kit
Testis-Development Protein Nyd-Sp27 ELISA kit
PLCZ1 ELISA kit
output

Information sourced from Uniprot.org

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