• Human P2RX7 (Purinergic Receptor P2X, Ligand Gated Ion Channel 7) Sandwich ELISA Kit (STJE0011234)

Human P2RX7 (Purinergic Receptor P2X, Ligand Gated Ion Channel 7) Sandwich ELISA Kit (STJE0011234)

SKU:
STJE0011234

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.112ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This P2RX7 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: P2RX7
Gene ID: 5027
Uniprot ID: P2RX7_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Widely expressed with highest levels in brain and immune tissues.
Post Translational Modifications Phosphorylation results in its inactivation. ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel. Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface.
Function Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells.
Protein Name P2x Purinoceptor 7
P2x7
Atp Receptor
P2z Receptor
Purinergic Receptor
Database Links Reactome: R-HSA-139853
Reactome: R-HSA-418346
Reactome: R-HSA-844456
Reactome: R-HSA-9660826
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names P2x Purinoceptor 7 ELISA kit
P2x7 ELISA kit
Atp Receptor ELISA kit
P2z Receptor ELISA kit
Purinergic Receptor ELISA kit
P2RX7 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance