| Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). |
| Protein Name | 2'-5'-Oligoadenylate Synthase 3(2-5'Oligo(A Synthase 32-5a Synthase 3P100 OasP100oas |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-8983711Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | 2'-5'-Oligoadenylate Synthase 3 protein(2-5'Oligo(A Synthase 3 protein2-5a Synthase 3 proteinP100 Oas proteinP100oas proteinOAS3 proteinP proteinOKcl.4 protein |
Information sourced from Uniprot.org
