• Human OAS2 (2 NA, 5 Oligoadenylate Synthetase 2) Sandwich ELISA Kit (STJE0011152)

Human OAS2 (2 NA, 5 Oligoadenylate Synthetase 2) Sandwich ELISA Kit (STJE0011152)

SKU:
STJE0011152

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 1.24ng/mL
Detection Limit: 3.12-200ng/mL
Short Description: This OAS2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: OAS2
Gene ID: 4939
Uniprot ID: OAS2_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Myristoylation is not essential for its activity. Glycosylated. Glycosylation is essential for its activity.
Function Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates. Non-infected lobules would not be affected, allowing efficient pup feeding during infection.
Protein Name 2'-5'-Oligoadenylate Synthase 2
(2-5'Oligo(A Synthase 2
2-5a Synthase 2
P69 Oas / P71 Oas
P69oas / P71oas
Database Links Reactome: R-HSA-877300
Reactome: R-HSA-8983711
Reactome: R-HSA-909733
Cellular Localisation Cytoplasm
Perinuclear Region
Alternative ELISA Names 2'-5'-Oligoadenylate Synthase 2 ELISA kit
(2-5'Oligo(A Synthase 2 ELISA kit
2-5a Synthase 2 ELISA kit
P69 Oas / P71 Oas ELISA kit
P69oas / P71oas ELISA kit
OAS2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance